It takes ingenuity to handle binary integers in C without direct separator support. Long, unreadable binary sequences are a common problem for developers working with embedded systems, making logical operations and debugging more difficult. Although spaced binary literals are not permitted by the C standard, methods such as bitwise operations, macros, and prepared strings enable to overcome this limitation. Some strategies include applying pre-processing scripts for readability or visually grouping bits using custom formatting. When working with low-level protocols like I2C, where every bit matters, these techniques are crucial.